Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity - 0 views
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Nathan Goodyear on 13 Mar 12dysregulated cortisol metabolism plays a role in obesity. This study looked at obese men. Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol conversion. Additionally, increase cortisol metabolites were found. However, there was found to be an increase in 11-betaHSD1 activity in the adipose tissue increasing the cortisone to cortisol conversion indicating an increase in peripheral cortisol production.